Ingestion of jimsonweed can result in hallucinations. Despite this side effect, the differential diagnosis of jimsonweed toxicity can be difficult, in part, because routine drug screens do not detect this agent. Such a delay in diagnosis not only postpones treatment but may also result in the patient's death. Treatment involves gastric lavage, followed by supportive care. Life-threatening cases entail the cautious use of physostigmine salicylate.