Pinin protects astrocytes from cell death after acute ischemic stroke via maintenance of mitochondrial anti-apoptotic and bioenergetics functions.

Sujira MukdaChing-Yi TsaiSteve LeuJenq-Lin YangSamuel H H Chan

Published in: Journal of biomedical science (2019)

We conclude that the endogenous Pnn participates in neuroprotection after acute ischemic stroke by preserving the viability of astrocytes that survived the ischemic challenge via maintenance of mitochondrial anti-apoptotic and bioenergetics functions.

Keyphrases

acute ischemic stroke
cell death
oxidative stress
cell cycle arrest
cerebral ischemia
brain injury
ischemia reperfusion injury
signaling pathway
subarachnoid hemorrhage