Acetaminophen pharmacokinetics in infants and children with congenital heart disease.
Jay D HolladayPeter WinchJames Denzil MorseBrian Joseph AndersonChristopher T McKeeJulie Rice-WeimerJoseph D TobiasPublished in: Paediatric anaesthesia (2022)
Acetaminophen pharmacokinetics were characterized using a 2-compartment model with first-order elimination following cardiac bypass surgery in children. Population pharmacokinetic parameter estimates were similar to other studies in children. No differences were detected between patients with cyanotic and acyanotic heart disease.