Abnormal Cyclic Nucleotide Signaling at the Outer Mitochondrial Membrane In Sympathetic Neurons During the Early Stages of Hypertension.

Dan LiKun LiuHarvey DavisCalum RobertsonOliver C NeelyAdib TarafdarNi LiKonstantinos LefkimmiatisManuela ZaccoloDavid J Paterson

Published in: Hypertension (Dallas, Tex. : 1979) (2022)

When taken together, these results suggest that site-specific inhibition of PDE2A and PDE6D at the outer mitochondrial membrane may provide a therapeutic target to ameliorate cardiac sympathetic impairment during the onset of hypertension.

Keyphrases

blood pressure
oxidative stress
spinal cord
left ventricular
heart failure
arterial hypertension