Chronic activation of anti-oxidant pathways and iron accumulation in epileptogenic malformations.
Till S ZimmerGiulia CiriminnaA ArenaJ J AninkA KorotkovF E JansenW van HeckeW G SplietP C van RijenJ C BaayenS IdemaN R RensingM WongJ D MillsErwin Alexander van VlietE AronicaPublished in: Neuropathology and applied neurobiology (2020)
Our results demonstrate that early and sustained activation of anti-oxidant signalling and dysregulation of iron metabolism are a pathological hallmark of FCD IIb and TSC. Our findings suggest novel therapeutic strategies aimed at controlling the pathological link between both processes.