Zac1 and the Imprinted Gene Network program juvenile NAFLD in response to maternal metabolic syndrome.
Marine BaptissartChristine M BradishBrie S JonesEvan WalshJesse TehraniVicmarie Marrero-ColonSanya MehtaDereje D JimaSeh Hoon OhAnna Mae DiehlTiffany FougerayHervé GuillouMichael CowleyPublished in: Hepatology (Baltimore, Md.) (2022)
Our findings identify a pathway linking maternal MetS exposure during postnatal development to the programming of juvenile NAFLD, and provide support for the hypothesis that imprinted genes play a central role in metabolic disease programming.
Keyphrases
- metabolic syndrome
- birth weight
- genome wide
- genome wide identification
- pregnancy outcomes
- preterm infants
- quality improvement
- genome wide analysis
- copy number
- solid phase extraction
- dna methylation
- pregnant women
- gene expression
- type diabetes
- mass spectrometry
- body mass index
- adipose tissue
- high resolution
- network analysis