Variant APOL1 protein in plasma associates with larger particles in humans and mouse models of kidney injury.
Michael AndrewsTeruhiko YoshidaClark M HendersonHannah PflaumAyako McGregorJoshua A LiebermanIan H de BoerTomas VaisarJonathan HimmelfarbBryan KestenbaumJoon-Yong ChungStephen M HewittBriana A SantoBrandon GinleyPinaki SarderAvi Z RosenbergTaichi MurakamiJeffrey B KoppZsuzsanna KuklenyikAndrew N HoofnaglePublished in: PloS one (2022)
These results suggest that plasma APOL1 is dynamic and contributes to the progression of kidney disease in humans, which may have implications for treatment of APOL1-associated kidney disease and for kidney transplantation.