Mitovesicles secreted into the extracellular space of brains with mitochondrial dysfunction impair synaptic plasticity.

Mitovesicle impairment of LTP is a previously undescribed paracrine-like mechanism by which EVs modulate synaptic activity, demonstrating that mitovesicles are active participants in the propagation of cellular and functional homeostatic changes in the context of neurodegenerative disorders.