IL-15-deficient mice develop enhanced allergic responses to airway allergen exposure.
Clinton B MathiasC M SchrammL A GuernseyC A WuS H PolukortJ RovattiJ Ser-DolanskyE SecorS S SchneiderR S ThrallH L AguilaPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2017)
These data demonstrate that mice with an endogenous IL-15 deficiency are susceptible to the development of severe, enhanced Th2-mediated AAD, which can be regulated by CD8+ T cells. Furthermore, the development of disease as well as allergen-specific Th2 responses occurs despite deficiencies in several IL-15-dependent cell types including NK, NKT, and γδ T cells, suggesting that these cells or their subsets are dispensable for the induction of AAD in IL-15-deficient mice.