SARS-CoV-2-Induced ARDS Associates with MDSC Expansion, Lymphocyte Dysfunction, and Arginine Shortage.
Florian ReizineMathieu LesouhaitierMurielle GregoireKieran PinceauxArnaud GacouinAdel MaamarBenoit PainvinChristophe CamusYves Le TulzoPierre TattevinMatthieu RevestAudrey Le BotAlice BallerieBerengère Cador-RousseauMathieu LederlinThomas LebouvierYoann LauneyMaelle LatourClotilde VerdyDelphine RossilleSimon Le GallouJoelle DulongCaroline MoreauClaude BendavidMikael RousselMichel CogneKarin TarteJean-Marc TadiéPublished in: Journal of clinical immunology (2021)
The present study reports a critical role for MDSC in COVID-19-associated ARDS. Our findings open the possibility of arginine supplementation as an adjuvant therapy for these ICU patients, aiming to reduce immunosuppression and help virus clearance, thereby decreasing the duration of mechanical ventilation, nosocomial infection acquisition, and mortality.
Keyphrases
- mechanical ventilation
- sars cov
- acute respiratory distress syndrome
- intensive care unit
- end stage renal disease
- respiratory failure
- extracorporeal membrane oxygenation
- nitric oxide
- ejection fraction
- newly diagnosed
- coronavirus disease
- respiratory syndrome coronavirus
- chronic kidney disease
- peritoneal dialysis
- risk factors
- cardiovascular events
- oxidative stress
- high glucose
- emergency department
- diabetic rats
- peripheral blood
- patient reported outcomes
- cardiovascular disease
- drug induced
- staphylococcus aureus
- type diabetes
- coronary artery disease
- methicillin resistant staphylococcus aureus