Research is essential to the development, maintenance, and success of interventional radiology (IR) as a primary specialty. IR physicians must embrace a more sophisticated research approach toward the procedures we perform and the diseases we treat to accompany our elevated status. Identifying impactful research needs and directing a comprehensive research portfolio will anchor our position as an essential specialty within a thriving health care system. Doing so will ensure that this historic opportunity is maximized for the benefit of IR physicians, IR trainees, and, ultimately, IR patients.