Drug retention of biologics and Janus kinase inhibitors in patients with rheumatoid arthritis: the ANSWER cohort study.

Kosuke Ebina Yuki Etani Yuichi Maeda Yasutaka Okita Makoto Hirao Wataru Yamamoto Motomu Hashimoto Koichi Murata Ryota Hara Koji Nagai Yuri Hiramatsu Yonsu Son Hideki Amuro Takayuki Fujii Takaichi Okano Yo Ueda Masaki Katayama Tadashi Okano Shotaro Tachibana Tomoyuki Kamenaga Atsushi Kumanogoh Seiji Okada Ken Nakata

Published in: RMD open (2023)

TNFi (HR=1.52, 95% CI: 1.37 to 1.68) and CTLA4-Ig (HR=1.14, 95% CI: 1.00 to 1.30) showed a higher overall drug discontinuation rate, excluding non-toxicity and remission, than aIL-6R.

Keyphrases

oxidative stress
adverse drug
emergency department
disease activity
rheumatoid arthritis