The pluripotent factor OCT4A enhances the self-renewal of human dental pulp stem cells by targeting lncRNA FTX in an LPS-induced inflammatory microenvironment.
Hong HongKai ZengCan ZhouXiaochuan ChenZhezhen XuMengjie LiLu LiuQian ZengQian TaoXi WeiPublished in: Stem cell research & therapy (2023)
OCT4A was found to be a crucial factor maintaining the self-renewal of hDPSCs by transcriptionally targeting FTX in an inflammatory microenvironment. Moreover, we proposed a novel function of FTX in negatively regulating the pluripotency and multilineage differentiation capacity of hDPSCs. The hierarchical organization between OCT4A and FTX expanded the understanding of the network between transcription factors and lncRNAs in fine-tuning the pluripotency/differentiation balance of adult stem cells, and provided prospective targets for optimizing dental-derived stem cell sources for regenerative endodontics.
Keyphrases
- stem cells
- lps induced
- optical coherence tomography
- diabetic retinopathy
- inflammatory response
- transcription factor
- optic nerve
- oxidative stress
- endothelial cells
- embryonic stem cells
- cell therapy
- long non coding rna
- induced pluripotent stem cells
- cancer therapy
- young adults
- genome wide identification
- drug delivery
- genome wide analysis