High resolution imaging and five-year tuberculosis contact outcomes.
Hanif EsmailAnna K CoussensFriedrich ThienemannBianca SossenSandra L MukasaJames M WarwickRene T GoliathNashreen Omar DaviesEmily DouglassAmanda JacksonFrancisco LakayElizabeth M StreicherJacob E MunroMarilou H BarriosTorben HeinsohnLiana MacphersonDylan SheerinSaalikha AzizKeboile SeroleRemy DaroowalaArshad TaliepPetri AhlersStephanus T MalherbeRory BowdenRobin Mark WarrenKatharina RonacherLaura E ViaMelanie BahloKaren Rita JacobsonCharles R HorsburghPadmini SalgameDavid AllandClifton Earl BarryJoanne L FlynnJerrold J EllnerRobert John WilkinsonPublished in: medRxiv : the preprint server for health sciences (2023)
These findings challenge the latent/active TB paradigm demonstrating that subclinical disease exists up to 4 years prior to microbiological detection and/or symptom onset. There are important implications for screening and management of TB.
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