Mechanism of Action of a Chinese Herbal Compound Containing Quercetin, Luteolin, and Kaempferol in the Treatment of Vitiligo Based on Network Pharmacology and Experimental Verification.

Ziqian Xu Yihui XieJun SongJuntao Huang Weimin Shi

Published in: Evidence-based complementary and alternative medicine : eCAM (2022)

Based on the results of network pharmacology analysis and experimental verification, QA, LU, and KA can be utilized to protect PIG1 cells by inhibiting oxidative stress and reducing the intracellular level of ROS. This may explain the underlying mechanism of BST therapy and provide a novel strategy for the treatment of vitiligo.

Keyphrases

oxidative stress
induced apoptosis
dna damage
signaling pathway
cell death
stem cells
reactive oxygen species
cell cycle arrest
ischemia reperfusion injury
bone marrow
network analysis
cell therapy
diabetic rats
heat shock protein