Copy number variation profiling in pharmacogenetics CYP-450 and GST genes in Colombian population.
Brian RamírezMaría José Niño-OrregoDaniel CárdenasKevin Enrique ArizaKarol QuinteroNora Constanza Contreras BravoCaroll Tamayo-AgudeloMaría Alejandra GonzálezPaul LaissueDora Janeth Fonseca MendozaPublished in: BMC medical genomics (2019)
Our results describe, for the first time, the genomic profile of CNVs in a subgroup of Colombian population in GST and CYP-450 genes. GST genes indicated greater genetic variability than CYP-450 genes. The data obtained contributes to the knowledge of genetic profiles in Latin American subgroups. Although the clinical relevance of CNVs has not been fully established, it is a valuable source of pharmacogenetic variability data with potential involvement in the response to medications.