Severe psychiatric disorders and general medical comorbidities: inflammation-related mechanisms and therapeutic opportunities.
Antônio Lúcio TeixeiraLais Bhering MartinsMichael BerkMoisés Evandro BauerPublished in: Clinical science (London, England : 1979) (2022)
Individuals with severe psychiatric disorders, such as mood disorders and schizophrenia, are at increased risk of developing other medical conditions, especially cardiovascular and metabolic diseases. These medical conditions are underdiagnosed and undertreated in these patients contributing to their increased morbidity and mortality. The basis for this increased comorbidity is not well understood, possibly reflecting shared risks factors (e.g. lifestyle risk factors), shared biological mechanisms and/or reciprocal interactions. Among overlapping pathophysiological mechanisms, inflammation and related factors, such as dysbiosis and insulin resistance, stand out. Besides underlying the association between psychiatric disorders and cardiometabolic diseases, these mechanisms provide several potential therapeutic targets.
Keyphrases
- healthcare
- risk factors
- insulin resistance
- bipolar disorder
- end stage renal disease
- oxidative stress
- metabolic syndrome
- chronic kidney disease
- ejection fraction
- early onset
- newly diagnosed
- adipose tissue
- type diabetes
- peritoneal dialysis
- human health
- weight loss
- climate change
- skeletal muscle
- drug induced
- sleep quality
- patient reported outcomes
- depressive symptoms