Postnatal metformin treatment alters rat Sertoli cell proliferation and daily sperm production.

Gustavo Marcelo RindoneAgostina GorgaEliana Herminia PellizzariMaría Del Carmen CamberosMaría Noel GalardoVanina Gabriela Da RosMariano Gabriel BuffoneSilvina Beatriz MeroniMaría Fernanda Riera

Published in: Andrology (2021)

These results suggest that metformin treatment may lead to a decrease in Sertoli cell proliferation, a concomitant altered expression of cell cycle regulators and ultimately, a reduction in daily sperm production in adult animals.

Keyphrases

cell cycle
cell proliferation
physical activity
transcription factor
oxidative stress
preterm infants
pi k akt
binding protein