Genomic investigation of multispecies and multivariant bla NDM outbreak reveals key role of horizontal plasmid transmission.
Nenad MacesicAdelaide S M DennisJane HawkeyBen VezinaJessica A WisniewskiHugh CottinghamLuke V BlakewayTaylor HarshegyiKatherine PragastisGnei Zweena BadoordeenPauline BassAndrew J StewardsonAmanda DennisonDenis W SpelmanAdam W J JenneyAnton Y PelegPublished in: Infection control and hospital epidemiology (2024)
Increased NDM case numbers were due to local circulation of 2 epidemic plasmids with extensive interstrain transfer. Our findings underscore the challenges of outbreak detection when horizontal transmission of plasmids is the primary mode of spread.