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Down-regulated FTO and ALKBH5 co-operatively activates FOXO signaling through m6A methylation modification in HK2 mRNA mediated by IGF2BP2 to enhance glycolysis in colorectal cancer.

Mujie YeJinhao ChenFeiyu LuMinghui ZhaoSuwen WuChunhua HuPing YuJingbao KanJianan BaiYe TianQiyun Tang
Published in: Cell & bioscience (2023)
In conclusion, our study revealed the FTO-ALKBH5/IGF2BP2/HK2/FOXO1 axis as a mechanism of aberrant m6A modification and glycolysis regulation in CRC.
Keyphrases
  • pi k akt
  • transcription factor
  • binding protein
  • signaling pathway
  • high glucose
  • dna methylation
  • cell proliferation
  • genome wide
  • growth hormone
  • gene expression
  • endothelial cells