Epigallocatechin Gallate Protects against MNNG-Induced Precancerous Lesions of Gastric Carcinoma in Rats via PI3K/Akt/mTOR Pathway.

Feiye ZhuYanli XuJieli PanMeiya LiFangming ChenGuanqun Xie

Published in: Evidence-based complementary and alternative medicine : eCAM (2021)

EGCG ameliorated pathological lesions of PLGC and exerted the effect of apoptosis promotion in PLGC rats. The apoptotic pathway triggered by EGCG may be related to inhibition of PI3K/Akt/mTOR pathway. It provided a theoretical basis for the PLGC treatment and gastric cancer prevention.

Keyphrases

cell death
oxidative stress
diabetic rats
high glucose
cell cycle arrest
signaling pathway