Templated Insertions Are Associated Specifically with BRCA2 Deficiency and Overall Survival in Advanced Ovarian Cancer.
Grace MooreRahul MajumdarSimon N PowellAtif J KhanNils WeinholdShen YinDaniel S HigginsonPublished in: Molecular cancer research : MCR (2022)
Small, templated insertions indicative of theta-mediated end-joining likely can be used in conjunction with other HRD mutational signatures as a prognostic tool for patient response to therapies targeting HR deficiency.