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Templated Insertions Are Associated Specifically with BRCA2 Deficiency and Overall Survival in Advanced Ovarian Cancer.

Grace MooreRahul MajumdarSimon N PowellAtif J KhanNils WeinholdShen YinDaniel S Higginson
Published in: Molecular cancer research : MCR (2022)
Small, templated insertions indicative of theta-mediated end-joining likely can be used in conjunction with other HRD mutational signatures as a prognostic tool for patient response to therapies targeting HR deficiency.
Keyphrases
  • replacement therapy
  • case report
  • working memory
  • transcranial magnetic stimulation
  • genome wide
  • free survival
  • gene expression
  • dna damage
  • prefrontal cortex