Structurally Diverse Sesquiterpenoids with Anti-neuroinflammatory Activity from the Endolichenic Fungus Cryptomarasmius aucubae.
Yi-Jie ZhaiJian-Nan LiYu-Qi GaoLin-Lin GaoDa-Cheng WangWen-Bo HanJin-Ming GaoPublished in: Natural products and bioprospecting (2021)
Two new sterpurane sesquiterpenoids named sterpurol D (1) and sterpurol E (2), and one skeletally new sesquiterpene, cryptomaraone (3), bearing a 5,6-fused bicyclic ring system, along with five known ones, sterpurol A (4), sterpurol B (5), paneolilludinic Acid (6), murolane-2α, 9β-diol-3-ene (7) and (-)-10,11-dihydroxyfarnesol (8) were isolated from an endolichenic fungus Cryptomarasmius aucubae. The structures of the new compounds were elucidated by analysis of NMR spectroscopic spectra and HRESIMS data. The absolute configurations of 1 and 2 were established by spectroscopic data analysis and comparison of specific optical rotation, as well as the biosynthetic consideration. Additionally, compounds 1, 2, 4-6, and 8 showed significant nitric oxide (NO) production inhibition in Lipopolysaccharide (LPS)-induced BV-2 microglial cells with the IC50 values ranging from 9.06 to 14.81 μM.
Keyphrases
- lps induced
- data analysis
- inflammatory response
- high resolution
- nitric oxide
- molecular docking
- induced apoptosis
- cell cycle arrest
- magnetic resonance
- lipopolysaccharide induced
- electronic health record
- high speed
- molecular dynamics simulations
- oxidative stress
- signaling pathway
- spinal cord
- big data
- machine learning
- cell death
- spinal cord injury
- molecular dynamics