Missense mutation of ISL1 (E283D) is associated with the development of type 2 diabetes.
Juan ZhangRong ZhangChanwei LiuXiaoxu GeYing WangFusong JiangLangen ZhuangTiantian LiQihan ZhuYanyan JiangYating ChenMing LuYanzhong WangMeisheng JiangYanjun LiuLimei Liu
Published in: Diabetologia (2024)
mutation as a novel causative factor for type 2 diabetes, and suggested that targeting transcription factor ISL1 could offer an innovative avenue for the precise treatment of human type 2 diabetes.