Early Gastric Cancer: identification of molecular markers able to distinguish submucosa-penetrating lesions with different prognosis.
Chiara MolinariGianluca TedaldiFrancesca RebuzziPaolo MorgagniLaura CapelliSara RavaioliMaria Maddalena TumedeiEmanuela ScarpiAnna TomezzoliRiccardo BernasconiMaria Raffaella AmbrosioAlessia D'IgnazioLeonardo SolainiFrancesco LimarziGiorgio ErcolaniGiovanni MartinelliPaola UliviLuca SaragoniPublished in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2020)
Our analyses revealed that clinico-pathological parameters, microsatellite status and frequency of TP53 mutations do not seem to distinguish Pen subgroups. Conversely, the amplification of GATA6 was associated with Pen B, as well as the overexpression of MUC6 and the TP53mut/LOH significantly characterized Pen A.