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Insertional translocation involving an additional nonchromothriptic chromosome in constitutional chromothripsis: Rule or exception?

Nehir Edibe KurtasLuciano XumerleUrsula GiussaniAlessandra PansaLaura CardarelliVeronica BertiniAngelo ValettoThomas LiehrMaria Clara BonagliaEdoardo ErrichielloMassimo DelledonneOrsetta Zuffardi
Published in: Molecular genetics & genomic medicine (2018)
Our findings show that (a) both simple and complex unbalanced rearrangements may result by the recombination of a cryptic parental balanced chromothripsis and that (b) insertional translocations are the spy of more complex rearrangements and not simply a three-breakpoint event.
Keyphrases
  • dna damage
  • dna repair
  • gene expression
  • oxidative stress
  • dna methylation