Cellular and Humoral Immune Responses to Vaccination for COVID-19 Are Negatively Impacted by Senescent T Cells: A Case Report.
Eliane Aparecida Rosseto-WelterSilvia Sanches RodriguesAmanda Braga de FigueiredoCarolina Nunes FrançaDanielle Bruna Leal OliveiraAndré Luís Lacerda BachiJônatas Bussador do AmaralRicardo Andreotti SiqueiraLaiz Camerão BentoAna Paula da SilvaNydia Strachman BacalCarlos Eduardo Dos Santos FerreiraCristóvão Luis Pitangueira MangueiraJoão Renato Rebello PinhoPublished in: Vaccines (2023)
CoronaVac elicited an early cellular response, followed by a humoral response, which dropped 90 days after the second dose. The booster with the Pfizer vaccine significantly enhanced these responses. Furthermore, a pro-inflammatory systemic status was found in volunteers who presented senescent T cells, which could putatively impair the immune response to vaccination.