Login / Signup

Colonization profile and duration by multi-resistant organisms in a prospective cohort of newborns after hospital discharge.

Andressa Midori SakaiThayla Nadrielly Aparecida Nicolino IensueKauana Olanda PereiraRenata Lima da SilvaLeila Garcia de Oliveira PegoraroMarta Silva de Almeida SalvadorRenne RodriguesJaqueline Dario CapobiangoNathália Aparecida Andrade de SouzaMarsileni PelissonEliana Carolina VesperoLucy Megumi Yamauchi LioniMarcia Regina Eches PeruginiSueli Fumie Yamada-OgattaEdilaine Giovanini RossettoGilselena Kerbauy
Published in: Revista do Instituto de Medicina Tropical de Sao Paulo (2020)
The aim of this study was to determine the spontaneous decolonization period and characteristics in a prospective cohort of newborns colonized by multidrug-resistant organisms, after their discharge from the neonatal intensive care unit. Multidrug resistance is defined as bacterial non-susceptibility to ≥ 1 agent of ≥ 3 antimicrobial categories. In total, 618 newborns were included in the study, of which 173 (28.0%) presented a positive culture for multidrug-resistant microorganisms, and of these, 52 (30.1%) were followed up in this study. The most frequent intrinsic factors were be born by cesarean section (86.5%), prematurity (84.6%), and very low birth weight (76.9%). The extrinsic factors were having remained hospitalized for an average of 27 days, during which 67.3% were submitted to invasive procedures and 88.5% received antimicrobials. The intrinsic and extrinsic factors of newborns were not associated to a decolonization period longer or shorter than 3 months, which was the average period of decolonization found in the present study. From the totality of colonization cultures sampled at hospital discharge, the Gram-negative Extended Spectrum β-lactamase producing bacteria were the most common, with 28.9% of babies colonized by Klebsiella spp. The median period of decolonization by multidrug-resistant microorganisms in the newborns population after hospital discharge was 3 months, but was highly dependent on the microbial species, and this period was not associated to any intrinsic and extrinsic factors of the newborn.
Keyphrases
  • multidrug resistant
  • low birth weight
  • gram negative
  • preterm infants
  • gestational age
  • human milk
  • drug resistant
  • preterm birth
  • staphylococcus aureus
  • cord blood
  • klebsiella pneumoniae
  • pseudomonas aeruginosa