Rapid Wane and Recovery of XBB Sublineage Neutralization After Sequential Omicron-based Vaccination in Solid Organ Transplant Recipients.

Trevor S Johnston Camille Hage Aura T AbedonSnigdha PandaJennifer L Alejo Yolanda Eby Dorry L Segev Aaron A R Tobian Andrea L Cox William A Werbel Andrew H Karaba

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2024)

Durability of variant neutralization in solid organ transplant recipients following Omicron-containing boosters is unknown. We report wane in XBB.1.5 neutralization by 3 months following a first bivalent booster, improved by a second booster; hybrid immunity improved peak, and duration of neutralization. Boosting at 3 to 6 months appears necessary to maintain neutralization.

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