Biological variation of intact fibroblast growth factor 23 measured on a fully automated chemiluminescent platform.

Antonín JaborZdenek KubíčekJitka KomrskováTereza VackováJiří VymětalíkJanka Franeková

Published in: Annals of clinical biochemistry (2019)

The measurement of iFGF23 demonstrated a CVA less than 4% during the experimental estimation of biological variation. The total imprecision was less than 7% in the EP15-A2 experiment. The CVI values of iFGF23 in healthy persons were 14.2 (SD ANOVA) and 12.5% (CV ANOVA), respectively. The CVG was 13.4%, and the resulting index of individuality was 1.06. The reference change value was less than 41%. The availability of this automated assay for iFGF23 with well-characterized biological variation data delivers opportunities for improved availability and application of this assay clinically.

Keyphrases

high throughput
machine learning
deep learning
single cell
electronic health record
big data
data analysis