Effects of Recombinant Human Lecithin Cholesterol Acyltransferase on Lipoprotein Metabolism in Humans.
Gissette Reyes-SofferAnastasiya MatveyenkoJames LignosNelsa MatienzoLeinys S Santos-BáezAntonio Hernandez-OnoLau YungRenu NandakumarSasha A SinghMasanori AikawaRichard T GeorgeHenry N GinsbergPublished in: Arteriosclerosis, thrombosis, and vascular biology (2024)
Our results suggest that an acute increase in LCAT activity drives greater flux of cholesteryl ester through the reverse cholesterol transport pathway without significantly altering the clearance and production of the main HDL proteins and without affecting the metabolism of APOB100-lipoproteins. Long-term elevations of LCAT might, therefore, have beneficial effects on total body cholesterol balance and atherogenesis.