Accumulation of advanced glycation end products (AGEs) is associated with the severity of aortic stenosis in patients with concomitant type 2 diabetes.
Magdalena KopytekMichał ZąbczykPiotr MazurAnetta UndasJoanna NatorskaPublished in: Cardiovascular diabetology (2020)
Our study suggests that poorly-controlled diabetes leads to increased AGEs and RAGE valvular accumulation, which at least partially, might result in AS progression in DM patients.
Keyphrases
- ejection fraction
- aortic stenosis
- type diabetes
- glycemic control
- aortic valve
- transcatheter aortic valve replacement
- end stage renal disease
- aortic valve replacement
- cardiovascular disease
- transcatheter aortic valve implantation
- newly diagnosed
- left ventricular
- atrial fibrillation
- prognostic factors
- peritoneal dialysis
- coronary artery disease
- metabolic syndrome
- heart failure
- adipose tissue
- skeletal muscle