Gut Microbial Ecosystem in Parkinson Disease: New Clinicobiological Insights from Multi-Omics.

Ai-Huey TanChun Wie ChongShen-Yang LimIvan Kok Seng YapCindy Shuan Ju TehMun Fai LokeSze-Looi SongJiun Yan TanBan Hong AngYong Qi TanMee Teck KhoJeff BowmanSanjiv MahadevaHoi Sen YongAnthony E Lang

Published in: Annals of neurology (2021)

Gut microbial function is altered in PD, characterized by differentially abundant metabolic features that provide important biological insights into gut-brain pathophysiology. Their clinical relevance further supports a role for microbial metabolites as potential targets for the development of new biomarkers and therapies in PD. ANN NEUROL 2021;89:546-559.

Keyphrases

parkinson disease
microbial community
deep brain stimulation
human health

climate change
ms ms
resting state

white matter
single cell
multiple sclerosis

risk assessment
blood brain barrier
neural network