Non-invasive tumor decoding and phenotyping of cerebral gliomas utilizing multiparametric 18F-FET PET-MRI and MR Fingerprinting.
Johannes HauboldAydin DemirciogluMarcel GratzMartin GlasKarsten WredeUlrich SureGerald AntochKathy KeyvaniMathias NittkaStephan KannengiesserVikas GulaniMark GriswoldKen HerrmannMichael ForstingFelix NensaLale UmutluPublished in: European journal of nuclear medicine and molecular imaging (2019)
18F-FET PET-MRI and MR fingerprinting enable high-quality imaging-based tumor decoding and phenotyping for differentiation of low-grade vs. high-grade gliomas and for prediction of the mutational status of ATRX, IDH1, and 1p19q. These initial results underline the potential of 18F-FET PET-MRI to serve as an alternative to invasive tissue characterization.