Porcine Mandibular Bone Marrow-Derived Mesenchymal Stem Cell (BMSC)-Derived Extracellular Vesicles Can Promote the Osteogenic Differentiation Capacity of Porcine Tibial-Derived BMSCs.
Qun ZhaoXing ZhangYou LiZhizhen HeKang QinEva Miriam BuhlÜmit MertKlemens HorstFrank HildebrandElizabeth Rosado BalmayorJohannes GrevenPublished in: Pharmaceutics (2024)
Our results indicate that mBMSC-EVs can promote the osteogenic differentiation of tBMSCs in vitro. The results also provide insights into the osteogenic mechanism of mBMSCs via TLR4/NF-κB signaling pathway activation. This discovery promises a fresh perspective on the treatment of bone fractures or malunions, potentially offering a novel therapeutic method.
Keyphrases
- mesenchymal stem cells
- signaling pathway
- bone marrow
- umbilical cord
- pi k akt
- total knee arthroplasty
- toll like receptor
- inflammatory response
- small molecule
- epithelial mesenchymal transition
- cell therapy
- lps induced
- induced apoptosis
- oxidative stress
- bone mineral density
- combination therapy
- cell proliferation
- body composition
- endoplasmic reticulum stress
- smoking cessation