CASPASE-8 gene polymorphisms (rs13416436 and rs2037815) are not associated with preeclampsia development in Brazilian women.

Ivanir Celso OrlandoSarah Cristina Sato Vaz TanakaMarly Aparecida Spadotto BalarinSueli Riul da SilvaCristina Wide Pissetti

Published in: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (2017)

It seems that CASP8 gene polymorphisms (rs13416436 and rs2037815) are not important candidates for the development of preeclampsia. Other genes related to the apoptosis process or other polymorphisms in this gene should be studied in order to understand better the etiology of preeclampsia.

Keyphrases

early onset
pregnancy outcomes
cell death
genome wide
oxidative stress
polycystic ovary syndrome
pregnant women
endoplasmic reticulum stress
type diabetes
cell cycle arrest
adipose tissue
cell proliferation
skeletal muscle
metabolic syndrome
insulin resistance