Altered cytochrome 2E1 and 3A P450-dependent drug metabolism in advanced ovarian cancer correlates to tumour-associated inflammation.

Sebastian TrousilPatrizia LeeRobert J EdwardsLynn MaslenJingky P Lozano-KuehneRamya RamaswamiEric O AboagyeStephen ClarkeChristopher LiddleRohini Sharma

Published in: British journal of pharmacology (2019)

CYP enzyme activity is differentially affected by the presence of tumour-associated inflammation, affecting particularly CYP2E1- and CYP3A-mediated drug metabolism, and may have profound implications for drug development and prescribing in oncological settings.

Keyphrases

oxidative stress
adverse drug
primary care
intellectual disability
rectal cancer
drug induced
prostate cancer
robot assisted
autism spectrum disorder