Clinicoradiological and neuropathological evaluation of primary progressive aphasia.
Dror ShirNick Corriveau-LecavalierCamilo Bermudez NogueraLeland BarnardNha Trang Thu PhamHugo BothaJoseph R DuffyHeather M ClarkRene L UtianskiDavid S KnopmanRonald C PetersenBradley F BoeveMelissa E MurrayAivi T NguyenR Ross ReichardDennis W DicksonGregory S DayWalter K KremersNeill R Graff-RadfordDavid T JonesMary M MachuldaJulie A FieldsJennifer L WhitwellKeith Anthony JosephsJonathan Graff-RadfordPublished in: Journal of neurology, neurosurgery, and psychiatry (2024)
Distinguishing 3R-taupathy and 4R-tauopathy in agPPA may rely on apraxia of speech presence. Additional linguistic and clinical features can aid neuropathology prediction. Our data-driven brain metabolism decomposition approach effectively predicts underlying neuropathology.