Association of HTR1A gene polymorphisms with obsessive-compulsive disorder and its treatment response: the influence of sex and clinical characteristics.
Niyousha AlizadehNasim NosratZohreh JahaniAbolhassan AhmadianiSareh AsadiJamal ShamsPublished in: The International journal of neuroscience (2018)
We concluded that among the HTR1A polymorphisms, only the association of rs10042486 CT genotype and OCD was statistically significant. The association of C-1019G with OCD by considering the age of onset and family history was just significant in the female patients. No significant association between the studied HTR1A SNPs with treatment response was observed. Acquiring both positive and negative pharmacogenetic outcomes in each population helps to select the appropriate medication for a particular patient with fewer side effects.
Keyphrases
- obsessive compulsive disorder
- end stage renal disease
- deep brain stimulation
- chronic kidney disease
- healthcare
- ejection fraction
- newly diagnosed
- computed tomography
- peritoneal dialysis
- metabolic syndrome
- genome wide
- magnetic resonance
- dna methylation
- positron emission tomography
- skeletal muscle
- genome wide association