A new house dust mite-driven and mast cell-activated model of asthma in the guinea pig.

Patricia Ramos-RamírezMalin NorebyJielu LiuJie JiSuado M AbdillahiHenric OlssonSven-Erik DahlénGunnar NilssonMikael Adner

Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2020)

Repeated intranasal HDM administration induces mast cell activation and hyperplasia together with an asthma-like pathophysiology in guinea pigs. This model may be suitable for mechanistic investigations of asthma, including evaluation of the role of mast cells.

Keyphrases

allergic rhinitis
chronic obstructive pulmonary disease
lung function
air pollution
climate change