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A new house dust mite-driven and mast cell-activated model of asthma in the guinea pig.

Patricia Ramos-RamírezMalin NorebyJielu LiuJie JiSuado M AbdillahiHenric OlssonSven-Erik DahlénGunnar NilssonMikael Adner
Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2020)
Repeated intranasal HDM administration induces mast cell activation and hyperplasia together with an asthma-like pathophysiology in guinea pigs. This model may be suitable for mechanistic investigations of asthma, including evaluation of the role of mast cells.
Keyphrases
  • allergic rhinitis
  • chronic obstructive pulmonary disease
  • lung function
  • air pollution
  • climate change