Melatonin increases bone mass in normal, perimenopausal, and postmenopausal osteoporotic rats via the promotion of osteogenesis.

Huanshuai GuanNing KongRun TianRuomu CaoGuanzhi LiuYiyang LiQilu WeiMing JiaoYutian LeiFangze XingPeng TianKunzheng WangPei Yang

Published in: Journal of translational medicine (2022)

Bone mass continuously decreased after ovariectomy, while melatonin increased bone mass and ameliorated bone metabolism in normal, perimenopausal, and postmenopausal osteoporotic rats due to the induction of osteogenic differentiation in BMSCs.

Keyphrases

bone mineral density
postmenopausal women
body composition
bone loss
bone regeneration
soft tissue
mesenchymal stem cells
bone marrow