Neuroprotective effects of verbascoside against Alzheimer's disease via the relief of endoplasmic reticulum stress in Aβ-exposed U251 cells and APP/PS1 mice.

Chunyue WangXueying CaiRuochen WangSiyu ZhaiYongfeng ZhangWenji HuYizhi ZhangDi Wang

Published in: Journal of neuroinflammation (2020)

The results confirmed that VB possesses significant neuroprotective effects, which are related to the reduction of ER stress. These findings support the status of VB as a potentially effective treatment for AD and warrant further research.

Keyphrases

induced apoptosis
endoplasmic reticulum stress
signaling pathway
oxidative stress
cell cycle arrest
type diabetes
cell proliferation