HIV-Associated Microbial Translocation May Affect Cytokine Production of CD56bright NK Cells via Stimulation of Monocytes.
Michael ToVinhGregor HörrChristoph HoffmeisterKristiyana DobrikovaChristina GotterJan RaabeKim M KaiserSarah AhmadClaudia FinnemannEyleen MatejecGudrun HackJenny BischoffGereon J RiekeCarolynne Schwarze-ZanderChristoph BoeseckeKathrin van BremenJan-Christian WasmuthAnna M Eis-HübingerHendrik StreeckHedda L VerhasseltJohannes OldenburgChristian P StrassburgJürgen K RockstrohUlrich SpenglerBenjamin KrämerJacob NattermannPublished in: The Journal of infectious diseases (2023)
The mechanisms involved in HIV-associated natural killer (NK) cell impairment are still incompletely understood. We observed HIV infection to be associated with increased plasma levels of IFABP, a marker for gut epithelial barrier dysfunction, and LBP, a marker for microbial translocation. Both IFABP and LBP plasma concentrations were inversely correlated with NK cell interferon-γ production, suggesting microbial translocation to modulate NK cell functions. Accordingly, we found lipopolysaccharide to have an indirect inhibitory effect on NK cells via triggering monocytes' transforming growth factor-β production. Taken together, our data suggest increased microbial translocation to be involved in HIV-associated NK cell dysfunction.
Keyphrases
- nk cells
- antiretroviral therapy
- hiv positive
- hiv infected
- microbial community
- transforming growth factor
- human immunodeficiency virus
- hiv testing
- hiv aids
- hepatitis c virus
- men who have sex with men
- dendritic cells
- epithelial mesenchymal transition
- oxidative stress
- south africa
- peripheral blood
- toll like receptor
- lps induced
- signaling pathway
- data analysis