A Case of Successful Allogeneic Hematopoietic Stem Cell Transplantation in a Severely Underweight Patient with Aplastic Anemia.
Lilija BancevičaAndrius ŽučenkaPublished in: Case reports in hematology (2024)
Allogeneic hematopoietic stem cell transplantation (alloHSTC) is considered definitive and the most effective treatment for young patients diagnosed with severe aplastic anemia. Low body mass index (BMI) is known to be associated with poorer outcomes in stem cell transplantation and higher mortality risks. Malnutrition negatively affects the patient's ability to mobilize stem cells, therefore reducing patients' stem cell production, although the patient's nutritional status improvement with enteral and parenteral nutrition may reduce the risks of stem cell graft failure and graft-vs-host disease (GVHD) occurrence. The present report demonstrates a severely underweight patient with aplastic anemia and a BMI of 11 kg/m 2 who was unsuccessfully treated with immunosuppressive therapy followed by alloHSTC.
Keyphrases
- allogeneic hematopoietic stem cell transplantation
- stem cells
- acute myeloid leukemia
- end stage renal disease
- acute lymphoblastic leukemia
- body mass index
- chronic kidney disease
- stem cell transplantation
- case report
- newly diagnosed
- ejection fraction
- peritoneal dialysis
- physical activity
- risk assessment
- squamous cell carcinoma
- low dose
- radiation therapy
- weight gain
- skeletal muscle
- early onset
- coronary artery disease
- iron deficiency
- risk factors
- adipose tissue
- smoking cessation
- climate change