Detection of cytogenomic abnormalities by OncoScan microarray assay for products of conception from formalin-fixed paraffin-embedded and fresh fetal tissues.

Jiadi WenBrittany GrommischAutumn DiAdamoHongyan ChaiSok Meng Evelyn NgPei HuiAllen BaleWinifred MakGuilin WangPeining Li

Published in: Molecular cytogenetics (2021)

OMA on POC-CF and POC-FFPE showed a high diagnostic yield of cytogenomic abnormalities. This approach circumvented the obstacles of CF from fresh specimens and fragmented DNA from fixed tissues and provided a reliable and effective platform for detecting cytogenomic abnormalities and monitoring true fetal result from maternal cell contamination.

Keyphrases

cystic fibrosis
high throughput
gene expression
single cell
cell therapy
drinking water
stem cells
pregnant women
health risk
pregnancy outcomes
loop mediated isothermal amplification
label free
birth weight
physical activity
mesenchymal stem cells
body mass index
real time pcr
gestational age