BCG-Related Inflammatory Syndromes in Severe Combined Immunodeficiency After TCRαβ+/CD19+ Depleted HSCT.

Alexandra Laberko Daria Yukhacheva Yulia Rodina Dmitriy Abramov Dmitriy Konovalov Svetlana Radygina Larisa Shelikhova Dmitriy Pershin Olga Kadnikova Mikhail A Maschan Alexey A Maschan Dmitry Balashov Anna Shcherbina

Published in: Journal of clinical immunology (2020)

BCG-vaccinated SCID patients undergoing allogeneic HSCT with TCRαβ+/CD19+ graft depletion are at an increased risk of early and late BCG-IS. Anti-inflammatory therapy with IL-1 and IL-6 blockade is efficient in the prevention of early and treatment of late BCG-IS.

Keyphrases

patients undergoing
hematopoietic stem cell
anti inflammatory
regulatory t cells
stem cell transplantation
bone marrow
oxidative stress
early onset
stem cells
immune response
drug induced
dendritic cells