Intensity of Respiratory Cortical Arousals Is a Distinct Pathophysiologic Feature and Is Associated with Disease Severity in Obstructive Sleep Apnea Patients.
Katharina BahrVincent GeislerTilman HuppertzSergiu GroppaChristoph MatthiasHaralampos GouverisMuthuraman MuthuramanPublished in: Brain sciences (2021)
Each individual patient with OSA might have an individual pattern of RA intensity and duration indicating a distinct individual pathophysiological feature. Arousal intensity was significantly higher in hypopneic than in apneic events and may be related causally to the diminished (compared to apneas) respiratory distress associated with hypopneas. RA intensity in REM, NREM2 and NREM3 strongly correlated with ODI.
Keyphrases
- obstructive sleep apnea
- high intensity
- end stage renal disease
- rheumatoid arthritis
- machine learning
- ejection fraction
- newly diagnosed
- chronic kidney disease
- positive airway pressure
- deep learning
- disease activity
- case report
- prognostic factors
- ankylosing spondylitis
- systemic lupus erythematosus
- respiratory tract
- sleep apnea
- interstitial lung disease
- drug induced
- patient reported