99mTc-DPD scintigraphy in immunoglobulin light chain (AL) cardiac amyloidosis.

Candida Cristina Quarta Jiexin Zheng David F HuttSimona F GrigoreRicha ManwaniSajitha SachchithananthamShameem A MahmoodCarol J WhelanMarianna FontanaAna Martinez-NaharroLiza ChackoHelen J LachmannJulian David GillmoreClaudio RapezziPhilip N HawkinsAshutosh D Wechalekar

Published in: European heart journal. Cardiovascular Imaging (2021)

In this large cohort of patients with AL CA, 99mTc-DPD scintigraphy ∼40% of cases showed cardiac uptake, including grade 2-3 in 10% of all patients (25% of those with cardiac 99mTc-DPD uptake). Cardiac 99mTc-DPD uptake was associated with poorer cardiac function and outcomes. These data highlight the critical importance of ruling out AL amyloidosis in all patients with cardiac 99mTc-DPD uptake to ensure such patients are not assumed to have ATTR CA.

Keyphrases

left ventricular
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
patient reported outcomes
multiple myeloma
metabolic syndrome