Non-invasive diagnosis and surveillance of bladder cancer with driver and passenger DNA methylation in a prospective cohort study.
Yu XiaoLingao JuKaiyu QianWan JinGang WangYan ZhaoWei JiangNan LiuKai WuMinsheng PengRui CaoSheng LiHongjie ShiYan GongHang ZhengTongzu LiuYongwen LuoHaoli MaLuyuan ChangGang LiXinyue CaoYe TianZilin XuZhonghua YangLiuying ShanZhongqiang GuoDongai YaoXianlong ZhouXintong ChenZicheng GuoDongmei LiuSong XuChundong JiFang YuXin HongJun LuoHong CaoYi ZhangXing-Huan WangPublished in: Clinical and translational medicine (2022)
With the discovery of BLCA-specific DNAm signatures, targeted sequencing of ctDNA methylation outperforms FISH and DNA mutation to detect tumours, predict recurrence and make prognoses.