Separating the effects of 24-hour urinary chloride and sodium excretion on blood pressure and risk of hypertension: Results from PREVEND.
Joep van der LeeuwMartin H de BorstLyanne M KienekerStephan J L BakkerRon T GansevoortMaarten B RookmaakerPublished in: PloS one (2020)
UCl and uNa had similar positive but non-significant associations with blood pressure and risk of hypertension and their effects could not be disentangled. Hence, the alleged adverse effects of high salt intake could be due to sodium, chloride or both. This encourages further study into the effect of chloride in order to complement dietary recommendations currently focused on sodium alone.